AustralieFrV1, Main, Exploration, bibRecord, 002225

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Identifieur interne : 002225 ( Main/Exploration ); précédent : 002224; suivant : 002226

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Auteurs : Talita Duarte-Salles [France, Espagne] ; Sandeep Misra [États-Unis] ; Magdalena Stepien [France] ; Amelie Plymoth ; David Muller [France] ; Kim Overvad [Danemark] ; Anja Olsen [Danemark] ; Anne Tj Nneland [Danemark] ; Laura Baglietto [Australie] ; Gianluca Severi [Italie] ; Marie-Christine Boutron-Ruault [France] ; Renee Turzanski-Fortner [Allemagne] ; Rudolf Kaaks [Allemagne] ; Heiner Boeing [Allemagne] ; Krasimira Aleksandrova [Allemagne] ; Antonia Trichopoulou [Grèce] ; Pagona Lagiou [Grèce] ; Christina Bamia [Grèce] ; Valeria Pala ; Domenico Palli ; Amalia Mattiello [Italie] ; Rosario Tumino ; Alessio Naccarati [Italie] ; H. B As Bueno-De-Mesquita [Pays-Bas, Royaume-Uni, Malaisie] ; Petra H. Peeters [Royaume-Uni] ; Elisabete Weiderpass [Norvège, Suède, Finlande] ; J. Ram N Quir S [Espagne] ; Antonio Agudo [Espagne] ; Emilio Sánchez-Cantalejo [Espagne] ; Eva Ardanaz [Espagne] ; Diana Gavrila [Espagne] ; Miren Dorronsoro [Espagne] ; M Rten Werner [Suède] ; Oskar Hemmingsson [Suède] ; Bodil Ohlsson [Suède] ; Klas Sjöberg [Suède] ; Nicholas J. Wareham [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Kathryn E. Bradbury [Royaume-Uni] ; Marc Gunter [France, Royaume-Uni] ; Amanda J. Cross [Royaume-Uni] ; Elio Riboli [Royaume-Uni] ; Mazda Jenab [France] ; Pierre Hainaut [France] ; Laura Beretta [États-Unis]

Source :

Cancer prevention research (Philadelphia, Pa.) [ 1940-6207 ] ; 2016.

RBID : PMC:5010922

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Aire sous la courbe, Alphafoetoprotéines (analyse), Carcinome hépatocellulaire (sang), Carcinome hépatocellulaire (épidémiologie), Courbe ROC, Détection précoce de cancer (), Europe, Femelle, Humains, Incidence, Jeune adulte, Marqueurs biologiques tumoraux (sang), Mâle, Odds ratio, Ostéopontine (sang), Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du foie (sang), Tumeurs du foie (épidémiologie), Études cas-témoins.
MESH :
- analyse : Alphafoetoprotéines.
- sang : Carcinome hépatocellulaire, Marqueurs biologiques tumoraux, Ostéopontine, Tumeurs du foie.
- épidémiologie : Carcinome hépatocellulaire, Tumeurs du foie.
- Adulte, Adulte d'âge moyen, Aire sous la courbe, Courbe ROC, Détection précoce de cancer, Europe, Femelle, Humains, Incidence, Jeune adulte, Mâle, Odds ratio, Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Area Under Curve, Biomarkers, Tumor (blood), Carcinoma, Hepatocellular (blood), Carcinoma, Hepatocellular (epidemiology), Case-Control Studies, Early Detection of Cancer (methods), Europe, Female, Humans, Incidence, Liver Neoplasms (blood), Liver Neoplasms (epidemiology), Male, Middle Aged, Odds Ratio, Osteopontin (blood), ROC Curve, Young Adult, alpha-Fetoproteins (analysis).
MESH :
- chemical , analysis : alpha-Fetoproteins.
- chemical , blood : Biomarkers, Tumor, Osteopontin.
- blood : Carcinoma, Hepatocellular, Liver Neoplasms.
- epidemiology : Carcinoma, Hepatocellular, Liver Neoplasms.
- methods : Early Detection of Cancer.
- Adult, Aged, Aged, 80 and over, Area Under Curve, Case-Control Studies, Europe, Female, Humans, Incidence, Male, Middle Aged, Odds Ratio, ROC Curve, Young Adult.

Abstract

We previously identified osteopontin (OPN) as a promising marker for the early detection of hepatocellular carcinoma (HCC). In this study, we investigated the association between pre-diagnostic circulating OPN levels and HCC incidence in a large population-based cohort. A nested-case control study was conducted within the EPIC cohort. During a mean follow-up of 4.8 years, 100 HCC cases were identified. Each case was matched to two controls and OPN levels were measured in baseline plasma samples. Viral hepatitis, liver function and alpha-fetoprotein (AFP) tests were also conducted. Conditional logistic regression models were used to calculate multivariable odds ratio (OR) and 95% confidence intervals (95%CI) for OPN levels in relation to HCC. Receiver operating characteristics curves were constructed to determine the discriminatory accuracy of OPN alone or in combination with other liver biomarkers in the prediction of HCC. OPN levels were positively associated with HCC risk (per 10% increment, OR_{multivariable}=1.30; 95%CI:1.14–1.48). The association was stronger among cases diagnosed within two years of follow-up. Adding liver function tests to OPN improved the discriminatory performance for subjects who developed HCC (AUC=0.86). For cases diagnosed within two years, the combination of OPN and AFP was best able to predict HCC risk (AUC=0.88). The best predictive model for HCC in this low-risk population is OPN in combination with liver function tests. Within two years of diagnosis, the combination of OPN and AFP best predicted HCC development, suggesting that measuring OPN and AFP could identify high-risk groups independently of a liver disease diagnosis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010922

DOI: 10.1158/1940-6207.CAPR-15-0434
PubMed: 27339170
PubMed Central: 5010922

Affiliations:

Le document en format XML

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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal</wicri:regionArea>
<wicri:noRegion>Nuthetal</wicri:noRegion>
<wicri:noRegion>Nuthetal</wicri:noRegion>
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</author>
<author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name>
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<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea>
<wicri:noRegion>University of Athens Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Hellenic Health Foundation, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
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</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea>
<wicri:noRegion>University of Athens Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bamia, Christina" sort="Bamia, Christina" uniqKey="Bamia C" first="Christina" last="Bamia">Christina Bamia</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Hellenic Health Foundation, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea>
<wicri:noRegion>University of Athens Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pala, Valeria" sort="Pala, Valeria" uniqKey="Pala V" first="Valeria" last="Pala">Valeria Pala</name>
<affiliation><nlm:aff id="A18">Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano-Italy</nlm:aff>
<wicri:noCountry code="subfield">20133 Milano-Italy</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name>
<affiliation><nlm:aff id="A19">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence- Italy</nlm:aff>
<wicri:noCountry code="subfield">Florence- Italy</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Dipartimento Di Medicina, Clinica E Chirurgia, Federico II University, Naples, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento Di Medicina, Clinica E Chirurgia, Federico II University, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name>
<affiliation><nlm:aff id="A21">Cancer Registry and Histopathology Unit, “Civic - M.P. Arezzo” Hospital, ASP Ragusa (Italy)</nlm:aff>
<wicri:noCountry code="subfield">ASP Ragusa (Italy)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Naccarati, Alessio" sort="Naccarati, Alessio" uniqKey="Naccarati A" first="Alessio" last="Naccarati">Alessio Naccarati</name>
<affiliation wicri:level="3"><nlm:aff id="A22">Human Genetics Foundation, Torino Molecular and Genetic Epidemiology Unit, Torino, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Human Genetics Foundation, Torino Molecular and Genetic Epidemiology Unit, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H. B As" last="Bueno-De-Mesquita">H. B As Bueno-De-Mesquita</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A26">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</nlm:aff>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea>
<wicri:noRegion>Kuala Lumpur</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name>
<affiliation><nlm:aff id="A27">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff>
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</affiliation>
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<author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
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<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A30">Cancer Registry of Norway, NO-0304 Oslo, Norway</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="A31">Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, SE-171 Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, SE-171 Stockholm</wicri:regionArea>
<wicri:noRegion>SE-171 Stockholm</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Genetic Epidemiology, Folkhälsan Research Center, 00250 Helsinki, Finland</nlm:aff>
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<wicri:regionArea>Department of Genetic Epidemiology, Folkhälsan Research Center, 00250 Helsinki</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J. Ram N" last="Quir S">J. Ram N Quir S</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Public Health Directorate, Asturias, Spain</nlm:aff>
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<wicri:regionArea>Public Health Directorate, Asturias</wicri:regionArea>
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<author><name sortKey="Agudo, Antonio" sort="Agudo, Antonio" uniqKey="Agudo A" first="Antonio" last="Agudo">Antonio Agudo</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL.L’Hospitalet de Llobregat, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
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</affiliation>
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<author><name sortKey="Sanchez Cantalejo, Emilio" sort="Sanchez Cantalejo, Emilio" uniqKey="Sanchez Cantalejo E" first="Emilio" last="Sánchez-Cantalejo">Emilio Sánchez-Cantalejo</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="A36">CIBER Epidemiology and Public Health (CIBERESP), Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiology and Public Health (CIBERESP)</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name>
<affiliation wicri:level="1"><nlm:aff id="A36">CIBER Epidemiology and Public Health (CIBERESP), Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiology and Public Health (CIBERESP)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A37">Navarra Public Health Institute, Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Navarra Public Health Institute, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A38">Navarra Institute for Health Research (IdiSNA) Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Navarra Institute for Health Research (IdiSNA) Pamplona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gavrila, Diana" sort="Gavrila, Diana" uniqKey="Gavrila D" first="Diana" last="Gavrila">Diana Gavrila</name>
<affiliation wicri:level="1"><nlm:aff id="A36">CIBER Epidemiology and Public Health (CIBERESP), Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiology and Public Health (CIBERESP)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia</wicri:regionArea>
<wicri:noRegion>Murcia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name>
<affiliation wicri:level="1"><nlm:aff id="A40">Public Health Direction and CIBERESP-Biodonostia Research Institute, Basque Regional Health Department, San Sebastian, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Public Health Direction and CIBERESP-Biodonostia Research Institute, Basque Regional Health Department, San Sebastian</wicri:regionArea>
<wicri:noRegion>San Sebastian</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Werner, M Rten" sort="Werner, M Rten" uniqKey="Werner M" first="M Rten" last="Werner">M Rten Werner</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Public Health and Clinical Medicine, Umeå University</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Hemmingsson, Oskar" sort="Hemmingsson, Oskar" uniqKey="Hemmingsson O" first="Oskar" last="Hemmingsson">Oskar Hemmingsson</name>
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<country xml:lang="fr">Suède</country>
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</author>
<author><name sortKey="Ohlsson, Bodil" sort="Ohlsson, Bodil" uniqKey="Ohlsson B" first="Bodil" last="Ohlsson">Bodil Ohlsson</name>
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<country xml:lang="fr">Suède</country>
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</affiliation>
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<author><name sortKey="Sjoberg, Klas" sort="Sjoberg, Klas" uniqKey="Sjoberg K" first="Klas" last="Sjöberg">Klas Sjöberg</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Lund University, Malmö</wicri:regionArea>
<wicri:noRegion>Malmö</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A44">Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö</wicri:regionArea>
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<author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation wicri:level="4"><nlm:aff id="A46">Clinical Gerontology Unit, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Gerontology Unit, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge</wicri:regionArea>
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<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
<orgName type="university">Université de Cambridge</orgName>
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<author><name sortKey="Bradbury, Kathryn E" sort="Bradbury, Kathryn E" uniqKey="Bradbury K" first="Kathryn E" last="Bradbury">Kathryn E. Bradbury</name>
<affiliation wicri:level="4"><nlm:aff id="A47">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom</nlm:aff>
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<orgName type="university">Université d'Oxford</orgName>
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<author><name sortKey="Gunter, Marc" sort="Gunter, Marc" uniqKey="Gunter M" first="Marc" last="Gunter">Marc Gunter</name>
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<country xml:lang="fr">France</country>
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<affiliation wicri:level="3"><nlm:aff id="A25">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff>
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<author><name sortKey="Cross, Amanda J" sort="Cross, Amanda J" uniqKey="Cross A" first="Amanda J." last="Cross">Amanda J. Cross</name>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea>
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<region type="région" nuts="1">Grand Londres</region>
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<author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea>
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<author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name>
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<author><name sortKey="Hainaut, Pierre" sort="Hainaut, Pierre" uniqKey="Hainaut P" first="Pierre" last="Hainaut">Pierre Hainaut</name>
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</affiliation>
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<author><name sortKey="Beretta, Laura" sort="Beretta, Laura" uniqKey="Beretta L" first="Laura" last="Beretta">Laura Beretta</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea>
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</placeName>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population</title>
<author><name sortKey="Duarte Salles, Talita" sort="Duarte Salles, Talita" uniqKey="Duarte Salles T" first="Talita" last="Duarte-Salles">Talita Duarte-Salles</name>
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<affiliation wicri:level="3"><nlm:aff id="A2">Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain</nlm:aff>
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<author><name sortKey="Misra, Sandeep" sort="Misra, Sandeep" uniqKey="Misra S" first="Sandeep" last="Misra">Sandeep Misra</name>
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<author><name sortKey="Stepien, Magdalena" sort="Stepien, Magdalena" uniqKey="Stepien M" first="Magdalena" last="Stepien">Magdalena Stepien</name>
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<wicri:regionArea>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon</wicri:regionArea>
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<author><name sortKey="Plymoth, Amelie" sort="Plymoth, Amelie" uniqKey="Plymoth A" first="Amelie" last="Plymoth">Amelie Plymoth</name>
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</author>
<author><name sortKey="Muller, David" sort="Muller, David" uniqKey="Muller D" first="David" last="Muller">David Muller</name>
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<author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name>
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<author><name sortKey="Olsen, Anja" sort="Olsen, Anja" uniqKey="Olsen A" first="Anja" last="Olsen">Anja Olsen</name>
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</affiliation>
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<author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name>
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<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="3"><nlm:aff id="A8">Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A9">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="3"><nlm:aff id="A10">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Human Genetics Foundation (HuGeF), Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Lifestyle, genes and health: integrative trans-generational epidemiology, F-94805, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Lifestyle, genes and health: integrative trans-generational epidemiology, F-94805, Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A12">Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ Paris Sud, UMRS 1018, F-94805, Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A13">Gustave Roussy, F-94805, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Gustave Roussy, F-94805, Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Turzanski Fortner, Renee" sort="Turzanski Fortner, Renee" uniqKey="Turzanski Fortner R" first="Renee" last="Turzanski-Fortner">Renee Turzanski-Fortner</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal</wicri:regionArea>
<wicri:noRegion>Nuthetal</wicri:noRegion>
<wicri:noRegion>Nuthetal</wicri:noRegion>
<wicri:noRegion>Nuthetal</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aleksandrova, Krasimira" sort="Aleksandrova, Krasimira" uniqKey="Aleksandrova K" first="Krasimira" last="Aleksandrova">Krasimira Aleksandrova</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal</wicri:regionArea>
<wicri:noRegion>Nuthetal</wicri:noRegion>
<wicri:noRegion>Nuthetal</wicri:noRegion>
<wicri:noRegion>Nuthetal</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Hellenic Health Foundation, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea>
<wicri:noRegion>University of Athens Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Hellenic Health Foundation, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea>
<wicri:noRegion>University of Athens Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bamia, Christina" sort="Bamia, Christina" uniqKey="Bamia C" first="Christina" last="Bamia">Christina Bamia</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Hellenic Health Foundation, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea>
<wicri:noRegion>University of Athens Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pala, Valeria" sort="Pala, Valeria" uniqKey="Pala V" first="Valeria" last="Pala">Valeria Pala</name>
<affiliation><nlm:aff id="A18">Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano-Italy</nlm:aff>
<wicri:noCountry code="subfield">20133 Milano-Italy</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name>
<affiliation><nlm:aff id="A19">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence- Italy</nlm:aff>
<wicri:noCountry code="subfield">Florence- Italy</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Dipartimento Di Medicina, Clinica E Chirurgia, Federico II University, Naples, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento Di Medicina, Clinica E Chirurgia, Federico II University, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name>
<affiliation><nlm:aff id="A21">Cancer Registry and Histopathology Unit, “Civic - M.P. Arezzo” Hospital, ASP Ragusa (Italy)</nlm:aff>
<wicri:noCountry code="subfield">ASP Ragusa (Italy)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Naccarati, Alessio" sort="Naccarati, Alessio" uniqKey="Naccarati A" first="Alessio" last="Naccarati">Alessio Naccarati</name>
<affiliation wicri:level="3"><nlm:aff id="A22">Human Genetics Foundation, Torino Molecular and Genetic Epidemiology Unit, Torino, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Human Genetics Foundation, Torino Molecular and Genetic Epidemiology Unit, Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H. B As" last="Bueno-De-Mesquita">H. B As Bueno-De-Mesquita</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A26">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</nlm:aff>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea>
<wicri:noRegion>Kuala Lumpur</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name>
<affiliation><nlm:aff id="A27">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff>
<wicri:noCountry code="subfield">University Medical Center Utrecht</wicri:noCountry>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A28">MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatics, School of Public Health, Imperial College, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatics, School of Public Health, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø</wicri:regionArea>
<wicri:noRegion>Tromsø</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A30">Cancer Registry of Norway, NO-0304 Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Cancer Registry of Norway, NO-0304 Oslo</wicri:regionArea>
<wicri:noRegion>NO-0304 Oslo</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A31">Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, SE-171 Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, SE-171 Stockholm</wicri:regionArea>
<wicri:noRegion>SE-171 Stockholm</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Genetic Epidemiology, Folkhälsan Research Center, 00250 Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Genetic Epidemiology, Folkhälsan Research Center, 00250 Helsinki</wicri:regionArea>
<wicri:noRegion>00250 Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J. Ram N" last="Quir S">J. Ram N Quir S</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Public Health Directorate, Asturias, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Public Health Directorate, Asturias</wicri:regionArea>
<wicri:noRegion>Asturias</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Agudo, Antonio" sort="Agudo, Antonio" uniqKey="Agudo A" first="Antonio" last="Agudo">Antonio Agudo</name>
<affiliation wicri:level="3"><nlm:aff id="A34">Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL.L’Hospitalet de Llobregat, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL.L’Hospitalet de Llobregat, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sanchez Cantalejo, Emilio" sort="Sanchez Cantalejo, Emilio" uniqKey="Sanchez Cantalejo E" first="Emilio" last="Sánchez-Cantalejo">Emilio Sánchez-Cantalejo</name>
<affiliation wicri:level="1"><nlm:aff id="A35">Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada</wicri:regionArea>
<wicri:noRegion>Granada</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A36">CIBER Epidemiology and Public Health (CIBERESP), Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiology and Public Health (CIBERESP)</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name>
<affiliation wicri:level="1"><nlm:aff id="A36">CIBER Epidemiology and Public Health (CIBERESP), Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiology and Public Health (CIBERESP)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A37">Navarra Public Health Institute, Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Navarra Public Health Institute, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A38">Navarra Institute for Health Research (IdiSNA) Pamplona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Navarra Institute for Health Research (IdiSNA) Pamplona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gavrila, Diana" sort="Gavrila, Diana" uniqKey="Gavrila D" first="Diana" last="Gavrila">Diana Gavrila</name>
<affiliation wicri:level="1"><nlm:aff id="A36">CIBER Epidemiology and Public Health (CIBERESP), Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiology and Public Health (CIBERESP)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia</wicri:regionArea>
<wicri:noRegion>Murcia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name>
<affiliation wicri:level="1"><nlm:aff id="A40">Public Health Direction and CIBERESP-Biodonostia Research Institute, Basque Regional Health Department, San Sebastian, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Public Health Direction and CIBERESP-Biodonostia Research Institute, Basque Regional Health Department, San Sebastian</wicri:regionArea>
<wicri:noRegion>San Sebastian</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Werner, M Rten" sort="Werner, M Rten" uniqKey="Werner M" first="M Rten" last="Werner">M Rten Werner</name>
<affiliation wicri:level="1"><nlm:aff id="A41">Department of Public Health and Clinical Medicine, Umeå University, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Public Health and Clinical Medicine, Umeå University</wicri:regionArea>
<wicri:noRegion>Umeå University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hemmingsson, Oskar" sort="Hemmingsson, Oskar" uniqKey="Hemmingsson O" first="Oskar" last="Hemmingsson">Oskar Hemmingsson</name>
<affiliation wicri:level="1"><nlm:aff id="A42">Department of Surgical and Perioperative Sciences, Umeå University, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Surgical and Perioperative Sciences, Umeå University</wicri:regionArea>
<wicri:noRegion>Umeå University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ohlsson, Bodil" sort="Ohlsson, Bodil" uniqKey="Ohlsson B" first="Bodil" last="Ohlsson">Bodil Ohlsson</name>
<affiliation wicri:level="1"><nlm:aff id="A43">Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Lund University, Malmö, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Lund University, Malmö</wicri:regionArea>
<wicri:noRegion>Malmö</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sjoberg, Klas" sort="Sjoberg, Klas" uniqKey="Sjoberg K" first="Klas" last="Sjöberg">Klas Sjöberg</name>
<affiliation wicri:level="1"><nlm:aff id="A43">Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Lund University, Malmö, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Lund University, Malmö</wicri:regionArea>
<wicri:noRegion>Malmö</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A44">Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö</wicri:regionArea>
<wicri:noRegion>Malmö</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name>
<affiliation wicri:level="1"><nlm:aff id="A45">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation wicri:level="4"><nlm:aff id="A46">Clinical Gerontology Unit, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Gerontology Unit, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge</wicri:regionArea>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
<orgName type="university">Université de Cambridge</orgName>
</affiliation>
</author>
<author><name sortKey="Bradbury, Kathryn E" sort="Bradbury, Kathryn E" uniqKey="Bradbury K" first="Kathryn E" last="Bradbury">Kathryn E. Bradbury</name>
<affiliation wicri:level="4"><nlm:aff id="A47">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Gunter, Marc" sort="Gunter, Marc" uniqKey="Gunter M" first="Marc" last="Gunter">Marc Gunter</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cross, Amanda J" sort="Cross, Amanda J" uniqKey="Cross A" first="Amanda J." last="Cross">Amanda J. Cross</name>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hainaut, Pierre" sort="Hainaut, Pierre" uniqKey="Hainaut P" first="Pierre" last="Hainaut">Pierre Hainaut</name>
<affiliation wicri:level="4"><nlm:aff id="A48">Institute for Advanced Biosciences (IAB), Inserm U1209, CNRS UMR5309, Université Grenoble-Alpes, Site Santé Grenoble, Allée des Alpes, La Tronche, France, 38700</nlm:aff>
<orgName type="university">Université Grenoble-Alpes</orgName>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beretta, Laura" sort="Beretta, Laura" uniqKey="Beretta L" first="Laura" last="Beretta">Laura Beretta</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cancer prevention research (Philadelphia, Pa.)</title>
<idno type="ISSN">1940-6207</idno>
<idno type="eISSN">1940-6215</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Area Under Curve</term>
<term>Biomarkers, Tumor (blood)</term>
<term>Carcinoma, Hepatocellular (blood)</term>
<term>Carcinoma, Hepatocellular (epidemiology)</term>
<term>Case-Control Studies</term>
<term>Early Detection of Cancer (methods)</term>
<term>Europe</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Liver Neoplasms (blood)</term>
<term>Liver Neoplasms (epidemiology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Osteopontin (blood)</term>
<term>ROC Curve</term>
<term>Young Adult</term>
<term>alpha-Fetoproteins (analysis)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Aire sous la courbe</term>
<term>Alphafoetoprotéines (analyse)</term>
<term>Carcinome hépatocellulaire (sang)</term>
<term>Carcinome hépatocellulaire (épidémiologie)</term>
<term>Courbe ROC</term>
<term>Détection précoce de cancer ()</term>
<term>Europe</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Jeune adulte</term>
<term>Marqueurs biologiques tumoraux (sang)</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Ostéopontine (sang)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tumeurs du foie (sang)</term>
<term>Tumeurs du foie (épidémiologie)</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>alpha-Fetoproteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers, Tumor</term>
<term>Osteopontin</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Alphafoetoprotéines</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Carcinoma, Hepatocellular</term>
<term>Liver Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Carcinoma, Hepatocellular</term>
<term>Liver Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Early Detection of Cancer</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Carcinome hépatocellulaire</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Ostéopontine</term>
<term>Tumeurs du foie</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Carcinome hépatocellulaire</term>
<term>Tumeurs du foie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Area Under Curve</term>
<term>Case-Control Studies</term>
<term>Europe</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>ROC Curve</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Aire sous la courbe</term>
<term>Courbe ROC</term>
<term>Détection précoce de cancer</term>
<term>Europe</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études cas-témoins</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">We previously identified osteopontin (OPN) as a promising marker for the early detection of hepatocellular carcinoma (HCC). In this study, we investigated the association between pre-diagnostic circulating OPN levels and HCC incidence in a large population-based cohort. A nested-case control study was conducted within the EPIC cohort. During a mean follow-up of 4.8 years, 100 HCC cases were identified. Each case was matched to two controls and OPN levels were measured in baseline plasma samples. Viral hepatitis, liver function and alpha-fetoprotein (AFP) tests were also conducted. Conditional logistic regression models were used to calculate multivariable odds ratio (OR) and 95% confidence intervals (95%CI) for OPN levels in relation to HCC. Receiver operating characteristics curves were constructed to determine the discriminatory accuracy of OPN alone or in combination with other liver biomarkers in the prediction of HCC. OPN levels were positively associated with HCC risk (per 10% increment, OR<sub>multivariable</sub>
=1.30; 95%CI:1.14–1.48). The association was stronger among cases diagnosed within two years of follow-up. Adding liver function tests to OPN improved the discriminatory performance for subjects who developed HCC (AUC=0.86). For cases diagnosed within two years, the combination of OPN and AFP was best able to predict HCC risk (AUC=0.88). The best predictive model for HCC in this low-risk population is OPN in combination with liver function tests. Within two years of diagnosis, the combination of OPN and AFP best predicted HCC development, suggesting that measuring OPN and AFP could identify high-risk groups independently of a liver disease diagnosis.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Danemark</li>
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<li>Finlande</li>
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<li>Malaisie</li>
<li>Norvège</li>
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<li>Catalogne</li>
<li>District de Karlsruhe</li>
<li>Grand Londres</li>
<li>Hovedstaden</li>
<li>Oxfordshire</li>
<li>Piémont</li>
<li>Rhône-Alpes</li>
<li>Texas</li>
<li>Utrecht (province)</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Athènes</li>
<li>Barcelone</li>
<li>Cambridge</li>
<li>Copenhague</li>
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<li>Heidelberg</li>
<li>Londres</li>
<li>Lyon</li>
<li>Melbourne</li>
<li>Oxford</li>
<li>Turin</li>
<li>Utrecht</li>
<li>Villejuif</li>
</settlement>
<orgName><li>Université Grenoble-Alpes</li>
<li>Université d'Oxford</li>
<li>Université de Cambridge</li>
<li>Université de Melbourne</li>
</orgName>
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<name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name>
</noCountry>
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<name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name>
<name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name>
<name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name>
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<name sortKey="Stepien, Magdalena" sort="Stepien, Magdalena" uniqKey="Stepien M" first="Magdalena" last="Stepien">Magdalena Stepien</name>
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<country name="Espagne"><region name="Catalogne"><name sortKey="Duarte Salles, Talita" sort="Duarte Salles, Talita" uniqKey="Duarte Salles T" first="Talita" last="Duarte-Salles">Talita Duarte-Salles</name>
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<name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name>
<name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name>
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<name sortKey="Gavrila, Diana" sort="Gavrila, Diana" uniqKey="Gavrila D" first="Diana" last="Gavrila">Diana Gavrila</name>
<name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J. Ram N" last="Quir S">J. Ram N Quir S</name>
<name sortKey="Sanchez Cantalejo, Emilio" sort="Sanchez Cantalejo, Emilio" uniqKey="Sanchez Cantalejo E" first="Emilio" last="Sánchez-Cantalejo">Emilio Sánchez-Cantalejo</name>
<name sortKey="Sanchez Cantalejo, Emilio" sort="Sanchez Cantalejo, Emilio" uniqKey="Sanchez Cantalejo E" first="Emilio" last="Sánchez-Cantalejo">Emilio Sánchez-Cantalejo</name>
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<country name="États-Unis"><region name="Texas"><name sortKey="Misra, Sandeep" sort="Misra, Sandeep" uniqKey="Misra S" first="Sandeep" last="Misra">Sandeep Misra</name>
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<name sortKey="Beretta, Laura" sort="Beretta, Laura" uniqKey="Beretta L" first="Laura" last="Beretta">Laura Beretta</name>
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<name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
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<name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
</country>
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</country>
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<name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name>
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<name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H. B As" last="Bueno-De-Mesquita">H. B As Bueno-De-Mesquita</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H. B As" last="Bueno-De-Mesquita">H. B As Bueno-De-Mesquita</name>
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<name sortKey="Bradbury, Kathryn E" sort="Bradbury, Kathryn E" uniqKey="Bradbury K" first="Kathryn E" last="Bradbury">Kathryn E. Bradbury</name>
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<name sortKey="Gunter, Marc" sort="Gunter, Marc" uniqKey="Gunter M" first="Marc" last="Gunter">Marc Gunter</name>
<name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
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<name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name>
</country>
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<name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
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<country name="Suède"><noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
</noRegion>
<name sortKey="Hemmingsson, Oskar" sort="Hemmingsson, Oskar" uniqKey="Hemmingsson O" first="Oskar" last="Hemmingsson">Oskar Hemmingsson</name>
<name sortKey="Ohlsson, Bodil" sort="Ohlsson, Bodil" uniqKey="Ohlsson B" first="Bodil" last="Ohlsson">Bodil Ohlsson</name>
<name sortKey="Sjoberg, Klas" sort="Sjoberg, Klas" uniqKey="Sjoberg K" first="Klas" last="Sjöberg">Klas Sjöberg</name>
<name sortKey="Sjoberg, Klas" sort="Sjoberg, Klas" uniqKey="Sjoberg K" first="Klas" last="Sjöberg">Klas Sjöberg</name>
<name sortKey="Werner, M Rten" sort="Werner, M Rten" uniqKey="Werner M" first="M Rten" last="Werner">M Rten Werner</name>
</country>
<country name="Finlande"><noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002225 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002225 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:5010922
   |texte=   Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27339170" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

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Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.